| Checklist |
What to do |
 |
Follow all appropriate procedures. |
Read Chemical Carcinogen Overview to learn how to determine if the substance you intend to use is a known or suspect carcinogen.
|
|
Obtain required approvals before beginning work. |
- Request prior approval and obtain a risk assessment from:
- The Animal Subjects Committee, (858) 534-6069, by submitting an online protocol
and
- Environment, Health & Safety's chemical safety officer, (858) 822-1579
- If risk assessment shows a reasonable risk to researchers or animal care staff, a meeting of all those at risk or concerned will be held to discuss safety considerations and animal care issues.
|
|
Follow these training guidelines. |
A principal investigator (PI) or a knowledgeable designee must provide appropriate safety training.
- Inform employees about handling the drug or chemical, its physical properties (including solubility), and health effects seen in experimental studies and other applicable sources.
- Review toxicological data from similar compounds if toxicological information is limited.
- Explain possible routes of exposure as appropriate:
- Inhalation
- Skin absorption
- Accidental injection
- Provide and train employees in the proper use of personal protective equipment and engineering controls to prevent exposure.
- Call (858) 534-1086 to provide the Animal Care staff with a summary of the training information.
|
|
Label containers and cages. |
- Label all containers with the following information:
- Name of the material
- Concentration
- Warnings
- Protective measures
- Date, when appropriate
- Preparer's initials, when appropriate
- Label animal cages with the appropriate hazard communication information below for the first 48 hours following administration of dosing solutions:
- "Warning: Cancer Agent"
- "Caution: Cancer Suspect Agent"
- "Caution: Hazardous Chemical/ Drug"
Maintain the signage following this initial period, according to this criteria:
- Aqueous dosing solutions – Once the bedding has been changed, the warning sign can be removed.
- Oil-soluble dosing solutions – Maintain the signage for 96 hours.
|
|
Take these safety precautions when administering the substance. |
- Injection or gavage: Use syringes and intravenous sets with Luer-lock fittings, if possible, when material is given via injection or gavage.
- Perform priming into a sterile, alcohol-dampened gauze sponge.
- Do not prime sets or syringes into the sink or any open receptacle.
- All animals must be housed in micro-isolator cages.
- Diet: Use a closed-caging system if the substance must be administered in the diet. Mix all diets containing the hazardous material in closed containers inside a chemical fume hood or Class II Type B2 biosafety cabinet.
|
|
Dispose of hazardous waste properly. |
Animal bedding, waste, and water — in addition to waste chemicals —may be subject to hazardous waste disposal requirements.
|
